David Heber Selected Research

Hydrolyzable Tannins

1/2013	Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis.
10/2008	Multitargeted therapy of cancer by ellagitannins.
2/2008	Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo.
2/2006	Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells.

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David Heber Research Topics

Disease

62	Neoplasms (Cancer) 05/2020 - 02/2002
44	Prostatic Neoplasms (Prostate Cancer) 05/2020 - 09/2002
14	Weight Loss (Weight Reduction) 06/2021 - 11/2002
13	Breast Neoplasms (Breast Cancer) 01/2017 - 03/2002
12	Carcinogenesis 01/2017 - 02/2002
10	Obesity 06/2021 - 06/2003
9	Inflammation (Inflammations) 08/2019 - 11/2002
8	Body Weight (Weight, Body) 01/2021 - 09/2002
7	Overweight 06/2021 - 11/2007
7	Colonic Neoplasms (Colon Cancer) 03/2013 - 02/2002
5	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 05/2016 - 08/2006
5	Cardiovascular Diseases (Cardiovascular Disease) 12/2009 - 11/2002
4	Leukemia 07/2006 - 09/2002
4	Polyps 02/2006 - 02/2002
3	Erythema 09/2022 - 10/2019
3	Insulin Resistance 10/2020 - 05/2017
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2013 - 03/2008
3	Adenoma (Adenomas) 04/2011 - 12/2003
2	Type 2 Diabetes Mellitus (MODY) 01/2020 - 05/2009
2	Glucose Intolerance 01/2020 - 01/2015
2	Weight Gain 12/2018 - 06/2010
2	Hypertriglyceridemia 05/2017 - 04/2013
2	Malnutrition (Nutritional Deficiencies) 11/2016 - 11/2010
2	Food Addiction 01/2016 - 09/2013
2	Liver Neoplasms (Liver Cancer) 01/2015 - 01/2014
2	Esophageal Neoplasms (Esophageal Cancer) 01/2014 - 06/2006
2	Stomach Neoplasms (Stomach Cancer) 01/2014 - 10/2005
2	Morbid Obesity 09/2013 - 08/2002

Drug/Important Bio-Agent (IBA)

25	TeaIBA 05/2020 - 08/2002
20	PolyphenolsIBA 05/2020 - 05/2004
14	AndrogensIBA 05/2016 - 11/2003
11	Proteins (Proteins, Gene)FDA Link 01/2017 - 02/2006
8	Biomarkers (Surrogate Marker)IBA 08/2019 - 10/2004
8	PhytochemicalsIBA 01/2010 - 11/2002
8	herbal preparation PC-SPESIBA 08/2006 - 09/2002
6	QuercetinIBA 05/2020 - 01/2012
6	Prostate-Specific Antigen (Semenogelase)IBA 10/2013 - 07/2003
6	Dietary Fats (Dietary Fat)IBA 12/2011 - 07/2003
5	Glucose (Dextrose)FDA LinkGeneric 06/2021 - 04/2013
5	AntioxidantsIBA 04/2021 - 11/2007
5	LipidsIBA 01/2017 - 01/2005
5	Estrogens (Estrogen)FDA Link 01/2017 - 03/2002
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2016 - 08/2002
5	NF-kappa B (NF-kB)IBA 04/2015 - 12/2003
5	Vitamin D FDA LinkGeneric 01/2013 - 02/2002
5	EnzymesIBA 11/2012 - 08/2006
5	CalciumIBA 07/2012 - 02/2002
5	ellagitanninIBA 02/2010 - 09/2007
4	Ellagic AcidIBA 10/2020 - 01/2010
4	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-oneIBA 10/2020 - 01/2013
4	FlavonoidsIBA 04/2015 - 02/2006
4	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 03/2003
4	Hydrolyzable TanninsIBA 01/2013 - 02/2006
4	Messenger RNA (mRNA)IBA 11/2012 - 07/2003
4	Androgen Receptors (Androgen Receptor)IBA 04/2011 - 11/2003
3	Melanins (Melanin)IBA 09/2022 - 10/2019
3	Triglycerides (Triacylglycerol)IBA 06/2021 - 06/2010
3	Guanosine Triphosphate (GTP)IBA 05/2020 - 11/2012
3	Insulin (Novolin)FDA Link 01/2020 - 07/2003
3	SugarsIBA 05/2017 - 05/2004
3	Folic Acid (Vitamin M)FDA LinkGeneric 01/2015 - 04/2011
3	Biological ProductsIBA 01/2014 - 11/2002
3	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2014 - 08/2006
3	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 01/2014 - 08/2010
3	Fish OilsIBA 01/2014 - 08/2006
3	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 12/2013 - 01/2012
3	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/2011 - 12/2002
3	Insulin-Like Growth Factor I (IGF-1)IBA 12/2011 - 07/2003
3	red yeast riceIBA 04/2011 - 07/2008
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2011 - 07/2008
3	Lovastatin (Mevacor)FDA LinkGeneric 04/2011 - 07/2008
3	LycopeneIBA 10/2010 - 11/2002
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2010 - 12/2002
3	Carotenoids (Carotene)IBA 09/2006 - 11/2002
2	CarbohydratesIBA 04/2021 - 06/2010
2	TabletsIBA 04/2021 - 01/2004
2	Polysaccharides (Glycans)IBA 08/2019 - 12/2017
2	xylooligosaccharideIBA 04/2018 - 01/2015
2	PrebioticsIBA 04/2018 - 01/2015
2	Sucrose (Saccharose)IBA 05/2017 - 09/2014
2	Ethanol (Ethyl Alcohol)IBA 01/2017 - 09/2002
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2016 - 01/2010
2	Docetaxel (Taxotere)FDA Link 05/2016 - 04/2015
2	Tumor Biomarkers (Tumor Markers)IBA 04/2015 - 08/2006
2	8-Hydroxy-2'-DeoxyguanosineIBA 04/2015 - 11/2012
2	MicronutrientsIBA 01/2015 - 09/2006
2	ORALIT (ORS)IBA 01/2014 - 09/2006
2	Insulin-Like PeptidesIBA 01/2014 - 07/2003
2	CarbonIBA 01/2014 - 04/2011
2	MethyltransferasesIBA 12/2013 - 11/2012
2	Leptin ReceptorsIBA 09/2013 - 10/2011

Therapy/Procedure

8	Therapeutics 06/2014 - 10/2003
6	Prostatectomy (Retropubic Prostatectomy) 05/2020 - 09/2008
6	Chemoprevention 01/2014 - 03/2005
5	Diet Therapy (Therapy, Diet) 06/2021 - 01/2005
4	Drug Therapy (Chemotherapy) 05/2016 - 03/2003
4	Fat-Restricted Diet (Diet, Fat Restricted) 12/2011 - 07/2003
3	Castration 05/2016 - 02/2004
2	Reducing Diet 04/2021 - 08/2019
2	Secondary Prevention 11/2016 - 12/2005